4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[6]arene shows IC50 of 2.2 and 3.0 uM for poly dA:dT-induced cell death and IL-1β release respectively.
4-Sulfonic calix[6]arene is effective at blocking dsDNA-induced inflammasome activation in LPS-primed human blood monocyte-derived macrophages (hMDMs).
4-Sulfonic calix[6]arene caused a dose-dependent inhibition in poly dA:dT-induced IFN-β release from murine BMDMs with IC50 of 10.72 uM, also reduced the phosphorylation of TBK1 and IRF-3 to a similar extent as the STING inhibitor H151.
物理化学性质&存储条件
分子量
1117.1
分子式
C42H36O24S6
外观性状
Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Sulfocalix[6]arene
参考文献
1. Jack P Green, et al. iScience. 2023 Apr 27;26(5):106758.
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